Summary: Nikki's life and career are threatened by her 650-pound weight. Determined to make a change, she undergoes weight-loss surgery.

Summary: Brittani has reached almost 600 pounds at just 32 years old. Though her husband loves large women, she lives in constant pain and hides her body from him for fear of rejection. In hopes of better health and a better marriage, she undergoes weight-loss surgery.

Summary: At over 700 pounds, Chad's weight is out of control and gastric bypass surgery is his last resort. He sells his house to be able to afford the surgery, but his recovery is complicated when he faces a medical crisis and fails to follow doctor's orders.

Summary: June, at almost 600 pounds, has coped with the tragic death of her son by eating. Confined to her house and unable to care for her three children, she must make a change and pursues gastric bypass surgery. Her girlfriend and primary caretaker Sadi supports her efforts.

Summary: At over 600 pounds, Dottie agrees to a drastic new diet and gastric bypass surgery in hopes of reclaiming her health and ability to care for her children. Her child's life-threatening emergency and her own self-sabotage threaten to derail her efforts.

Summary: At over 600 pounds, Gideon's is unable to work and completely dependent on his exhausted wife. Fearing an early demise and desperate for change, he uproots his family to undergo weight-loss surgery in hopes of reclaiming his life and health.

Summary: Ashley is just 26 years old and over 700 pounds. Her 5-year-old son is one of her primary caregivers and a motivating factor in making a major change. Knowing her life is on the line, she pursues weight loss surgery but faces medical setbacks and various struggles in the process.

Summary: At over 700 pounds, Teretha's life is confined to a bed -- a far cry from her former job representing Detroit's healthy eating program. Her adoring family fears losing her and hopes bariatric surgery will help save her life.

Summary: At 650 pounds, Randy's weight has led to the loss of his marriage and custody of his daughter. In a last ditch effort to save his life, he begins a rigorous diet to undergo weight loss surgery. He battles the temptation of fast food, as well as lingering depression, and struggles to keep his job.

Summary: At about 700 pounds, Milla is bedridden and unable to feed or bathe herself -- her five children care for her every need. She knows she must make a change for their sake as well as hers and in an attempt to reclaim her health, she moves to Texas to undergo weight-loss surgery.

Summary: Sean weighs almost 1,000 pounds at just 26 years old. His skin is so stretched it is tearing apart, and a massive growth protrudes from his side. With the support of his mother, he attempts weight-loss surgery to save his life.

Summary: Lupe, at almost 600 pounds, has been bedridden for 10 years and depends on her husband for all her needs. A cross-country move to Texas for weight-loss surgery is her last chance for change, but it may be too late.

Summary: Christina's weight loss has gone too far, too fast, and now threatens her life. After losing 300lbs, Paula must endure more surgery to deal with a body entirely covered in loose and sagging excess skin.

Summary: Zsalynn is excited for a fresh start but her 360-body lift at a Beverly Hills clinic proves more challenging than expected. Lonely and depressed since her gastric surgery, Olivia wants skin removal surgery but struggles to lose the weight to qualify.

Summary: Bettie Jo battles depression and a cancer diagnosis and when she finds out she's pregnant, she and her husband must find a way to cope. Susan suffers a major setback after surgery for her excess skin, thwarting her hopes to conquer her obesity.

Summary: Joe has come a long way from being morbidly obese...He's in love & contemplating proposing to his girlfriend. Just when life holds so much promise, his mom has a few health scares & forces Joe to balance his new love with his mother's health crisis.

Summary: Despite having lost 378lbs, Angela's knee pain combined with a history of obesity threatens everything she's worked for. Charity must find the strength to return to her goals of getting healthy.

Summary: Laura has lost 300lbs+ and is much less dependent on her husband Joey, who is now having trouble finding his way in the relationship. Marla, one of Dr. Now's most challenging patients returns and the fireworks begin all over again.

Summary: Pauline must find the will to keep up her weight-loss progress after a medical emergency. Chay's finally admitting what he's long known, that he's a transgender woman. But, the emotional stress of coming out could threaten his weight loss journey.