Summary: As Season 6 begins, Christian has news for Liz and the economic downturn has hit McNamara/Troy hard. But the boys might have found a lifesaver in Dr. Mike Hamoui (Mario Lopez), who's now in L.A. and has found a very profitable niche specialty. Meanwhile, Sean's relationship with Teddy Rowe (now played by Rose McGowan) has blossomed, and Matt, who's down on his luck, takes up mime.

Summary: Unable to sleep, Sean finds himself in an all-night diner, then in an ER; Liz goes after Christian's boat, leading him to offer Kimber a business deal; Sean and Christian remove tattoos from a teen obsessed with "the darker side of his personality."

Summary: Sean makes an important decision without consulting anyone; a morose Annie shows up in L.A. with a troubling medical condition; Christian gives Mike (Mario Lopez) tips on how to satisfy Kimber; and a new patient recognizes Teddy.

Summary: Christian struggles to understand a patient with big anger-management issues. Sean and Christian learn how Matt is earning an income, despite his attempts to keep it hidden from his family. Teddy arranges a camping trip with Sean, Annie and Conor in order to ease family tensions.

Summary: As Matt's crime spree catches up with him, Julia returns from New York to help in his recovery from surgery. Sean discovers devastating details about his marriage to Teddy. A new patient suffers from extreme separation anxiety.

Summary: When a newly married Erica threatens to take custody of Annie and Connor, Sean and Julia present a happy and united front to thwart her efforts. Christian bonds with a new patient as Mike reveals his future plans with Kimber.

Summary: Both Matt and Alexis Stone request unusual surgical procedures from Christian. Erica discovers the horrible truth about her new husband. After a lifetime of torment from her mother, Julia seeks revenge upon her.

Summary: A medical consultation with Liz's friend leads Christian to contemplate his relationship with Kimber. Sean begins to heal emotionally following an encounter with a perfection-seeking patient.

Summary: Christian's colossal financial debt leads him to deception. An unexpected visitor stirs insecurity within Christian and brings joy to Sean. Christian bonds with a young patient when he learns about his adoption.

Summary: Sean experiences an ethical and moral dilemma when McNamara/Troy is requested to perform a surgical procedure on a prison inmate. Kimber questions how far she will go to keep Christian when they receive life-changing news.

Summary: As they prepare to accept a prestigious award from their alma mater, Sean grows increasingly tired of covering up Christian's numerous indiscretions, a pattern going back to their first initial meeting in college. Kimber, now married to Christian and working as an interior decorator, heads up the remodeling of the McNamara/Troy practice, but continues to worry about Christian's fidelity. A new patient, suffering from the self-mutilating disorder Lesch–Nyhan syndrome, comes to McNamara/Troy for reconstructive surgery. Guest starring George Newbern.

Summary: Kimber grows frustrated by changes in Christian's physical appearance and his lack of respect for her new career, pushing her into the arms of her newest interior design client - Sean. Christian refuses to operate on a former supermodel who wants to surgically alter her face in an effort to look ordinary. Sean operates on Rupert Kenney (guest star Andy Comeau), a survivor of an eighteen-year coma who wants to both look and feel like his younger self.

Summary: Kimber reaches an emotional crossroads in regards to both her crumbling marriage to Christian and her affair with Sean. Meanwhile, Christian comes to a point of clarity over his marriage while experimenting with the dangerous sex act of erotic asphyxiation. Sean reunites with his humanitarian college friend, Dr Curtis Ryerson (guest star George Newbern), and becomes interested in performing more pro-bono surgery. McNamara/Troy fix the face of a man who survived a suicide attempt jumping from the Golden Gate Bridge. Guest starring Mario Lopez.

Summary: Kimber's suicide devastates Christian, who seeks emotional comfort with her estranged mother Brandy (guest star Melanie Griffith). Sean postpones his trip to Africa out of respect for Christian's pain. While Curtis (guest star George Newbern) is out of the country, Sean has an intimate encounter with his doctor wife (guest star Christine Adams). McNamara/Troy operate on a woman whose faced was horrifically scarred by the pet chimpanzee owned by her best friend Jane (guest star Frances Conroy), who herself is crippled with guilt over killing the animal to save her friend's life.

Summary: Sean and Christian are forced to re-visit past actions when Aurelia Gallardo (guest star Sandra Vergara), daughter of the deceased crime lord Escobar Gallardo (guest star Robert LaSardo), shows up at McNamara/Troy seeking answers about her father, stirring tremendous guilt within Sean. Christian's decision to operate on a small-town girl seeking surgery to make her a Hollywood "10" backfires, exposing an elaborate con in the process.

Summary: Sean and Christian begin psychotherapy in an attempt to resolve their escalating problems, with both revealing long-held secrets and their true perspectives on one another. Liz joins in with therapy too, revealing her own opinions on the Sean/Christian relationship, as well as a secret she has been keeping from Christian. Matt announces plans for the rest of his life, and introduces Sean and Christian to his fiancee Ramona (guest star Melonie Diaz).

Summary: McNamara/Troy face a troubling future when they discover a growing market in "injectable" procedures, which many believe will signal the death of plastic surgery. While under anesthetic during face lift surgery, Christian enters a dream world where he encounters past patients (guest stars Joan Rivers, Joan Van Ark and Donna Mills), experiences Sean's disappointments, comes to terms with Kimber's death, and meets his biological father (guest star Robert Davi). Liz dates a pharmaceutical rep (guest star Lesley Fera) separated from her husband. Guest starring George Newbern.

Summary: Ava Moore (guest star Famke Janssen) returns, requesting surgery to fix the face of her adopted son, who is suffering from Post kala-azar dermal leishmaniasis. Meanwhile, she discovers Matt's approaching nuptials, and once again manipulates her way into his life. At the same time, Julia arrives in Los Angeles with surprising news about her personal life, a revelation which provokes both Sean and Christian to make separate advances on her. Liz is told of the health of her unborn child. A married pair of elderly Holocaust survivors come to McNamara/Troy for surgical removal of their individual numbered tattoos, inflicted on them by the Nazis. But the removal provokes deep guilt in one of the pair. Guest starring Melonie Diaz.

Summary: In the series finale, Christian strikes a deal with Ava (Famke Janssen) in which he'd operate on baby Raphael as long as she stays away from Matt. While preparing to leave for London, Julia worries about Sean's state of mind. Liz is overwhelmed by Sean's excitement over her pregnancy. Both Julia's worries and a vision of Kimber force Christian to reconsider his long-standing relationship with Sean. An elderly Japanese porn star comes to McNamara/Troy requesting surgery to remove surgical scars before his big debut in an American porn movie. Guest starring Melonie Diaz.